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Architecture affects people. The architecture of hospitals contributes to the well-being and recovery of patients. This bold proposition dates back to the late 18th century, and has been a recurring theme in the functional development of hospital architecture ever since. The most recent manifestation of this was the phenomenon of ‘Evidence-Based Design’, which originated in the USA. This methodology compares the effects of various spatial factors and provided indisputable evidence that architecture does indeed work for the first time. The positive influence of architecture is one of the two cornerstones of ‘The Architecture of Hospitals’. The other is architecture as an historical discipline with a wide-ranging cultural dimension. The hospital, being a public and representative building with a special societal function, is the ideal vehicle to express this cultural dimension.